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S.No. API Intermediate CAS NO
Intermediate Name
1. 2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride 139525-77-2
2. 7-Methoxy-1-naphthylacetonitrile 138113-08-3
3. 2-(7-Methoxy-1-naphthyl)ethylamine 138113-09-4
4. Ethyl (7-methoxy-1,2,3,4-tetrahydro-1-naphthylidene)acetate
Aprepitant
5. (2R)-4-Benzyl-2-{(1R)-1-[3,5-Bis(trifluoromethyl) phenyl]ethoxy}morpholin-3-one 287930-75-0
6. 1-[3,5-bis(trifluoromethyl)phenyl]ethylbromide​ 160376-84-1
7. ​(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3-(4-fluorophenyl)-Morpholine 171482-05-6
8. Ethyl (7-methoxy-1,2,3,4-tetrahydro-1-naphthylidene)acetate
Dabigartan
9. {[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}acetic acid 872728-82-0
10. Ethyl 3-[{[3-methyl-4-(methylamino)phenyl]carbonyl}(pyridin-2-yl)amino]propanoate​ 212332-56-0
Infigratinib
11. 5-Amino-3 (trifluoromethyl) pyridine-2-carbonitrile 573762-62-6
12. 1-(6-Chloropyrimidin-4-yl)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methyl urea
Darifenacin
13. 1-Tosyl-3-(R)-(-)-hydroxy pyrrolidine 133034-00-1
14. 5-Chloroethyl-2,3- dihydrobenzofuran 943034-50-2
15. 3-(S)-(1-cyano-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl] pyrrolidine hydrobromide
Desloratadine
16. 8-chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta [1,2-b]pyridine 100643-71-8
17. 8-Bromo-6,11-dihydro-11-(1-methyl-4-piperdinylidene)-5H-benzo[5,6] cyclohepta [1,2-b]pyridine 130642-57-8
Dutasteride
18. 3- Oxo-4-aza-5α-androst-1-ene 17β-carboxamide​ 104239-97-6
Ezetimibe
19. (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4- (4-benzyloxyphenyl)azetidin-2-one 163222-32-0
Finasteride
20. 3-oxo-4-aza-5 alpha-androstan-17 beta-carboxylic acid 103335-55-3
21. 17β-(N-tert-Butylcarbamoyl-)3-Oxo-4-aza-5α-androstane 98319-24-5
Mirogabalin
22. [1R, 5S-]-3-Ethyl bicycle[3,2,0]hept-3-ene-6-one
Lamotrigine
23. 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine  84057-84-1
Lenalidomide
24. 3 Amino-piperidine-2,6-dione hydrochloride 24666-56-6
25. 2-Bromomethyl-3-nitrobenzoic acid methyl ester  98475-07-1
26. 3-(4-Nitro-1-oxo-1, 3-dihydro-isoindol-2yl)-piperidine-2,6-dione 827026-45-9​
Paliperidone
27. 3-(2-Chloroethyl)-6,7,8,9 Tetra Hydro-9 Hydroxy-2-Methyl-4H Pyrrido- (1,2-Alpha)-Pyrimidine-4-One 130049-82-0
28. ​6-Fluoro-3-(4-Piperidinyl)1,2-Benzisoxazole Hydrochloride 84163-13-3
Palonosetron
29. (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalene carboxamide 135729-78-1
30. ​5,6,7,8-Tetrahydronaphthoic  acid 4242-18-6
Risperidone
31. 6-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole Hydrochloride 84163-13-3
32. ​3-(2-Chloroethyl)-2-Methyl-6,7,8,9-Tetrahydro-4H-Pyrido-(1,2-a) Pyridine -4-one hydrochloride 93076-03-0
Rivaroxaban
33. 4-(4-Aminophenyl)morpholin-3-one 438056-69-0
34. 5-Chlorothiophene-2-carboxylic Acid 24065-33-6
35. ​(R)-4-[4-[(3-Chloro-2-hydroxypropyl)amino]phenyl]morpholin-3-one
Rivastigmine
36. (S)-1-(3-Methoxyphenyl)ethylamine  82796-69-8
37. S-(-)-[1-(3-methoxyphenyl)ethyl]-N,N-dimethylamine 889443-69-0
38. ​(S)-3-[1-(Dimethylamino)ethyl]phenol 139306-10-8
Rocuronium Bromide
39. (2b,3a,5a,16b,17b)-2-(4-Morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol  119302-20-4
40. (2b,3a,5a,16b,17b)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane 119302-24-8
41. ​2a 3a 16a 17a-diepoxy-17b-acetoxy-5a-androstane 50588-22-2
42. ​(2a,3a,5a,16b,17b)-2,3-Epoxy-16-(1-pyrrolidinyl)androstan-17-ol 119302-19-1
Sitagliptin Phosphate Monohydrate
43. 4-Oxo-4-[3-trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a] pyrazin-7(8H)-yl]- 1-(2,4,5-trifluorophenyl)butan-2-one 119302-20-4
44. (2Z)-4-Oxo-4-[3-trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a] pyrazin-7(8H)-yl] -1-(2,4,5-trifluorophenyl)butan-2-en-2-amine 119302-24-8
45. ​3-Amino-1-[3-trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a] pyrazin-7(8H)-yl] -4-(2,4,5-trifluorophenyl)-1-butanone 50588-22-2
46. ​3-(Trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4]triazolo [4,3-a] pyrazine Hydrochloride 119302-19-1
Solifenacin
47. 1-Phenyl-1,2,3,4-tetrahydro-isoquinoline 22990-19-8
48. (1S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline 118864-75-8
Teneligliptin
49. 1-(5-methyl-2-phenylpyrazol-3-yl)piperazine 401566-79-8
50. (S)-tert-butyl 3-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate 401564-36-1
Tolterodine Tartrate
51. 6-Methyl-4-phenylchroman-2-one 40546-94-9
52. Methyl 3-(2-methoxy-5-methylphenyl)-3-phenylpropanoate 401564-36-1
Valacyclovir
53. N-[(Phenylmethoxy)carbonyl]-L-valine 2-[(2-amino-1,6-dihydro-6-oxo- 9H-purin-9-yl)methoxy]ethyl ester 124832-31-1
Zafirlukast
54. Methyl 4-(bromomethyl)-3-methoxybenzoate 70264-94-7
55. {3 -[2-methoxy-4-carboxy-benZyl]-1 methyl-1H-indol-5-yl}-carbamic acid cyclopentyl ester
Zolmitriptan
56. (4S)-4-[(4-Aminophenyl)methyl]-2-oxazolidinone 152305-23-2
57. ethyl/methyl-3-[2-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)ethyl]-5-[(4S)-2-oxo- 1,3-oxazolan-4yl methyl]-1H-2-indole carboxylate
Zonisamide
58. 1,2-Benzisoxazole-3-acetic acid 4865-84-3
59. 1,2-Benzisoxazole-3-methanesulfonamide 68291-97-4
Fluoxetine
60. (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy] benzenepropanamine ​​54910-89-3

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